Fig. 2: Bcor and Dnmt3a loss induces a fully penetrant Acute Erythroid Leukemia (AEL). | Leukemia

Fig. 2: Bcor and Dnmt3a loss induces a fully penetrant Acute Erythroid Leukemia (AEL).

From: Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice

Fig. 2

A Kaplan–Mayer plot of mice survival according to the indicated genotypes (n = 8 to 24 per genotype) Bcor−/−Dnmt3a−/− mice display a median survival of 135 days (p < 0.0001, Logrank Test). B WBCs number (i) and MCV (ii) values in Bcor−/− Dnmt3a−/− leukemic mice compared to other control. (iii) Platelets number in Bcor−/−, Dnmt3a−/−, Bcor−/−Dnmt3a−/− and WT in PB of 3/4 months old mice. C i BM cytospin (top panel) hematossilin and eosin of the spleen (middle panel) and liver (bottom panel) in Bcor−/−, Dnmt3a−/− and WT control mice, showing the blasts infiltration. ×600 of magnification. ii Spleen weight to total body weight ratio in the indicated genotypes. Spleen ratio in Bcor−/−Dnmt3a−/− (n = 9) mice was two fold greater than in Dnmt3a−/−(n = 4), Bcor−/− (n = 6) and WT control (n = 8) (0.03378 ± 0.0077 and 0.0025 ± 0.000022 vs 0.0042 ± 0.00036 and 0.0035 ± 0.0026 p < 0.001 by one-way ANOVA analysis). *p < 0.05, **p < 0.01; ***p < 0.001 unpaired t-test with Welch’s correction.

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