Fig. 3: Bcor−/−Dnmt3a−/− shows a progressive expansion of immature erytrhoid cells populations. | Leukemia

Fig. 3: Bcor−/−Dnmt3a−/− shows a progressive expansion of immature erytrhoid cells populations.

From: Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice

Fig. 3

A TER119 + cKIT+ number of cells in BM (left) and spleen (right) in Bcor−/−Dnmt3a−/− leukemic mice and preleukemic compared to other control of 3/4 months old mice (n = 9, 6, 7, 6, 7). B Kaplan–Mayer plot of mice transplanted with 3 × 106 Bcor−/−Dnmt3a−/− leukemic cells n = 12. C Total number of cKIT+, Ter119+cKIT+, GR1 + MAC1+, MAC1 + GR−, CD3 and B220+, pre PipC and 3 months post PipC induction in PB of Bcor−/−Dnmt3a−/−, Bcor−/−, Dnmt3a−/− and WT control (pre n = 8,4,4,7; post n = 14,8,7,18). *p < 0.05, **p < 0.01; ***p < 0.001 unpaired t-test with Welch’s correction.

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