Fig. 2: Sensitivity to MDM2 inhibitor Nutlin-3a is regulated by several downstream miR-10a gene targets. | Leukemia

Fig. 2: Sensitivity to MDM2 inhibitor Nutlin-3a is regulated by several downstream miR-10a gene targets.

From: miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia

Fig. 2

a, b Correlations between mutation status of miR-10a downstream targets and sensitivity to Nutlin-3a and cytarabine in 888 cancer cell lines (GDSE database). Loss-of-function mutations in p53 and Rb, and chromosomal gain in CKDN1A (D; 2n = diploid, 3n = triploid, 4n = tetraploid) were significantly associated with resistance to Nutlin-3a (a) and cytarabine (b). (*p < 0.05, **p < 0.01; ***p < 0.001 by Student’s T test with error bars representing SD).

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