Fig. 3: miR-10a expression is correlated to MDM2 inhibitor sensitivity in vitro. | Leukemia

Fig. 3: miR-10a expression is correlated to MDM2 inhibitor sensitivity in vitro.

From: miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia

Fig. 3

a The endogenous expression of miR-10a in the NCI-60 cell line panel was correlated to sensitivity to 265 drugs screened in GDSC and Nutlin-3a was found to have the 4th strongest positive correlation with an r2 value of 0.17 (p < 0.05). b NCI-60 cell lines with endogenous expression below the median level had a mean IC50 of 34.1 µM, versus 95.7 µM for those above. c miR-10a displayed bimodal expression in 86 NPM1wt primary AML specimens assayed at diagnosis. (*p < 0.05, **p < 0.01; ***p < 0.001 by Student’s T test with error bars representing SD).

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