Table 3 Clinical and laboratory co-variates and therapy of subjects with haematological cancer and COVID-19.
Survivors N = 5 | Non-survivors N = 8 | P value | |
---|---|---|---|
Age, median (IQR), years | 35 (26, 37) | 39 (22, 54) | 0.665 |
Male sex | 2 | 5 | 0.826 |
Diagnosis | |||
Laboratory confirmed | 5 | 8 | >0.999 |
Clinically diagnosed | 0 | 0 | |
Staging | |||
Mild | 0 | 0 | 0.194 |
Common | 3 | 1 | |
Severe | 1 | 3 | |
Critical | 1 | 4 | |
Lung CT scan | |||
Patchy shadows | 1 | 1 | 0.487 |
Ground-glass opacity | 2 | 6 | |
Air space consolidation/whiteout | 1 | 0 | |
NAa | 1 | 1 | |
Laboratory findings (normal range) | |||
WBC, median (IQR), ×10E + 9/L (3.5–9.5) | 3.9 (2.6, 7.8) | 2.6 (0.5, 11.6) | 0.833 |
Neutrophils, median (IQR), ×10E + 9/L (1.8–6.3) | 2.7 (1.1, 6.8) | 0.7 (0.2, 6.5) | 0.626 |
Lymphocytes, median (IQR), ×10E + 9/L (1.1–3.2) | 0.7 (0.5, 0.9) | 0.5 (0.2, 0.7) | 0.329 |
Platelets, mean (SD), ×10E + 9/L (125–350) | 107.2 ± 86.0 | 54.1 ± 45.1 | 0.168 |
Haemoglobin, mean (SD), g/L (male, 130–175; female, 115–150) | 81.0 ± 19.3 | 71.9 ± 20.6 | 0.444 |
Prothrombin time, median (IQR), s (11.0–16.0) | 16.2 (15.6, 16.5) | 16.4 (13.7, 16.9) | >0.999 |
Activated partial thromboplastin time, mean (SD), s (28.0–43.5) | 44.7 ± 10.9 | 37.5 ± 16.3 | 0.408 |
D-dimer, median (IQR), mg/L (<0.5) | 0.6 (0.6, 0.6) | 1.3 (0.8, 2.4) | 0.030 |
Alanine aminotransferase, mean (SD), U/L (9–52) | 18.7 ± 10.3 | 18.9 ± 10.6 | 0.0975 |
Aspartate aminotransferase, mean (SD), U/L (14–36) | 26 ± 10 | 24 ± 14 | 0.766 |
Total bilirubin, median (IQR), μmol/L (3–22) | 11.1 (9.6, 12.9) | 11.7 (6.0, 17.2) | 0.943 |
Blood urea nitrogen, mean (SD), mmol/L (2.5–6.1) | 4.7 ± 2.2 | 5.5 ± 3.2 | 0.651 |
Serum creatinine, median (IQR), μmol/L (46–92) | 44 (41, 70) | 56 (43, 68) | 0.622 |
Lactate dehydrogenase, median (IQR), U/L, (114–240) | 275 (261, 296) | 184.0 (155, 413) | 0.268 |
Procalcitonin, mean (SD), ng/mL (<0.5) | 1.2 ± 1.2 | 4.0 ± 4.2 | 0.234 |
C-reactive protein, median (IQR), mg/L (<8.00) | 121 (37, 144) | 68 (64, 115) | >0.999 |
Co-infections | |||
Other viruses | 3 | 4 | >0.999 |
Bacteria | 3 | 8 | 0.248 |
Fungi | 3 | 6 | >0.999 |
Complications | |||
ARDS | 0 | 6 | 0.039 |
Acute renal failure | 0 | 1 | >0.999 |
Sepsis | 1 | 1 | >0.999 |
Treatment | |||
Umifenovir | 3 | 5 | >0.999 |
Interferon | 2 | 4 | >0.999 |
Antibiotics | 3 | 6 | >0.999 |
Corticosteroids | 1 | 3 | 0.962 |
Oxygen inhalation | 3 | 7 | 0.420 |
Non-invasive ventilation | 0 | 2 | 0.671 |
Mechanical ventilation | 0 | 1 | >0.999 |