Table 3 Clinical and laboratory co-variates and therapy of subjects with haematological cancer and COVID-19.

From: COVID-19 in persons with haematological cancers

 

Survivors N = 5

Non-survivors N = 8

P value

Age, median (IQR), years

35 (26, 37)

39 (22, 54)

0.665

 Male sex

2

5

0.826

Diagnosis

  Laboratory confirmed

5

8

>0.999

  Clinically diagnosed

0

0

 

Staging

  Mild

0

0

0.194

  Common

3

1

 

  Severe

1

3

 

  Critical

1

4

 

Lung CT scan

  Patchy shadows

1

1

0.487

  Ground-glass opacity

2

6

 

  Air space consolidation/whiteout

1

0

 

  NAa

1

1

 

Laboratory findings (normal range)

  WBC, median (IQR), ×10E + 9/L (3.5–9.5)

3.9 (2.6, 7.8)

2.6 (0.5, 11.6)

0.833

  Neutrophils, median (IQR), ×10E + 9/L (1.8–6.3)

2.7 (1.1, 6.8)

0.7 (0.2, 6.5)

0.626

  Lymphocytes, median (IQR), ×10E + 9/L (1.1–3.2)

0.7 (0.5, 0.9)

0.5 (0.2, 0.7)

0.329

  Platelets, mean (SD), ×10E + 9/L (125–350)

107.2 ± 86.0

54.1 ± 45.1

0.168

  Haemoglobin, mean (SD), g/L (male, 130–175; female, 115–150)

81.0 ± 19.3

71.9 ± 20.6

0.444

  Prothrombin time, median (IQR), s (11.0–16.0)

16.2 (15.6, 16.5)

16.4 (13.7, 16.9)

>0.999

  Activated partial thromboplastin time, mean (SD), s (28.0–43.5)

44.7 ± 10.9

37.5 ± 16.3

0.408

  D-dimer, median (IQR), mg/L (<0.5)

0.6 (0.6, 0.6)

1.3 (0.8, 2.4)

0.030

  Alanine aminotransferase, mean (SD), U/L (9–52)

18.7 ± 10.3

18.9 ± 10.6

0.0975

  Aspartate aminotransferase, mean (SD), U/L (14–36)

26 ± 10

24 ± 14

0.766

  Total bilirubin, median (IQR), μmol/L (3–22)

11.1 (9.6, 12.9)

11.7 (6.0, 17.2)

0.943

  Blood urea nitrogen, mean (SD), mmol/L (2.5–6.1)

4.7 ± 2.2

5.5 ± 3.2

0.651

  Serum creatinine, median (IQR), μmol/L (46–92)

44 (41, 70)

56 (43, 68)

0.622

  Lactate dehydrogenase, median (IQR), U/L, (114–240)

275 (261, 296)

184.0 (155, 413)

0.268

  Procalcitonin, mean (SD), ng/mL (<0.5)

1.2 ± 1.2

4.0 ± 4.2

0.234

  C-reactive protein, median (IQR), mg/L (<8.00)

121 (37, 144)

68 (64, 115)

>0.999

Co-infections

  Other viruses

3

4

>0.999

  Bacteria

3

8

0.248

  Fungi

3

6

>0.999

 Complications

   

  ARDS

0

6

0.039

  Acute renal failure

0

1

>0.999

  Sepsis

1

1

>0.999

Treatment

  Umifenovir

3

5

>0.999

  Interferon

2

4

>0.999

  Antibiotics

3

6

>0.999

  Corticosteroids

1

3

0.962

  Oxygen inhalation

3

7

0.420

  Non-invasive ventilation

0

2

0.671

  Mechanical ventilation

0

1

>0.999

  1. aLung CT scan data of subjects 1 and 5 were unavailable.