Table 3 Geometric means for isatuximab AUC 1W and Cmax across the dose range investigated.

From: A dose-finding Phase 2 study of single agent isatuximab (anti-CD38 mAb) in relapsed/refractory multiple myeloma

Isatuximab dose and regimen

AUC 1W (µg.h/ml)

Cmax C1D1 (µg/ml)

3 mg/kg Q2W (n = 23)

3023

41

10 mg/kg Q2W (n = 21)

13,837

153

10 mg/kg Q2W/Q4W (n = 25)

13,713

154

10 mg/kg Q2W for C1a (n = 46)

13,769

154

20 mg/kg QW/Q2W (n = 24)

25,596

279

  1. AUC 1W predicted cumulative area under the plasma concentration curve over the first week (0–168 h), C cycle, C1D1 cycle 1, day 1, Cmax maximum plasma concentration, QnW every n weeks.
  2. aC1–C2 for Cmax.
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