Fig. 2: Iterative Clustering and Guide Gene Selection (ICGS) analysis identifies a continuum of leukemic differentiation arrest. | Leukemia

Fig. 2: Iterative Clustering and Guide Gene Selection (ICGS) analysis identifies a continuum of leukemic differentiation arrest.

From: A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Fig. 2

a, b ICGS analysis of adult and pediatric T-ALLs (n = 48 samples) and AMLs (n = 76 samples) identifies 5 acute leukemia clusters (top). a Heatmap of expression of guide genes selected by ICGS. Columns represent individual samples. Bars on the top identify ICGS clusters. Rows represent genes, and bars on the side represent blocks of correlated genes. Selected enriched gene ontology groups are shown. Full gene lists are provided in Supplementary Table S5. Leukemic phenotypes are indicated in the bars below the heatmap. b Proportions of leukemic phenotypic groups in each ICGS cluster. c Mutations observed in T-ALL (n = 34) and AML (n = 45) samples ordered according to ICGS analysis in a. Only mutations found in at least two samples are shown.

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