Fig. 3: Transcriptional characterization of ICGS-defined clusters. | Leukemia

Fig. 3: Transcriptional characterization of ICGS-defined clusters.

From: A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Fig. 3

a–c: GSEAs using normal hematopoietic precursor transcriptional signatures of (a) all clusters, (b) interface Cluster 2 and (c) interface Cluster 3. Analyses restricted to either T-ALL, AML-like T-ALL, non-M0-AML and M0-AML are shown. Crossed out boxes indicate gene-sets that are not significantly enriched (FDR > 0.05). d Comparison of expression of genes related to B-cell development in interface and non-interface AMLs. e–f Enrichment of leukemic stem cell (LSC) [34] and mixed phenotype acute leukemia (MPAL) [35, 36] transcriptional signatures by GSEA of (e) all clusters, (f) interface Cluster 2 and (g) interface Cluster 3. Analyses restricted to either T-ALL, AML-like T-ALL, non-M0-AML and M0-AML are shown.

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