Fig. 1: Znhit1 deletion leads to acute expansion of HSCs. | Leukemia

Fig. 1: Znhit1 deletion leads to acute expansion of HSCs.

From: Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers

Fig. 1

a Hematopoietic lineages were sorted for examining the protein level of Znhit1. Fluorescence intensity of cells was calculated and shown on the point. b Flow cytometry of BM cells showed the gate, frequency, and number of LSKs from control (fl/+) and Znhit1−/− (fl/fl) mice at D7 (day 7) following pIpC treatment (n (the number of mice in each group) = 3). c Flow cytometry of BM cells showed the gate and frequency of SLAM LT-HSC from control (fl/+) and Znhit1−/− (fl/fl) mice at D7 following pIpC treatment (n = 3). d Flow cytometry of BM cells showed the gate and frequency of CD45.2+ LSKs from chimeric mice at D7 following Znhit1 deletion (n = 3). Results were representative of at least three independent experiments. Data were presented as mean ± s.d. *p < 0.05; **p < 0.01; ***p < 0.001.

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