Fig. 1: IKAROS binds to the promoter of the MTOR gene and suppresses mTOR expression. | Leukemia

Fig. 1: IKAROS binds to the promoter of the MTOR gene and suppresses mTOR expression.

From: Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia

Fig. 1

a IKAROS binding sites were identified by ChIP-Seq at the MTOR promoter in the (a) Nalm6 B-ALL cell lines and in a (b) B-ALL patient sample. c qChIP data confirming IKAROS binding at the MTOR promoter in primary B-ALL cells with wildtype IKZF1 (Patients 2–4) but not in IKZF1 haploinsufficiency (Patient 1). d Activity of the MTOR promoter (−1 kb to +500 bp) was assessed by luciferase reporter assay following transfection with IKZF1 plasmids or control vector in 293T cells.

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