Table 1 Univariate and multivariate analyses of baseline variables associated with deaths from infection versus deaths not due to infection.
Variable | Deaths from infection (%) | Deaths not due to infection (%) | Odds ratio | 95% confidence levels | P-value |
|---|---|---|---|---|---|
A. Univariate analysis: all trial patients with a known cause of death (n = 600) | |||||
≥2 lines of treatment | 194/258 (75) | 231/342 (68) | 1.46 | 1.01–2.09 | 0.04 |
Winter season | 149/258 (58) | 166/342 (49) | 1.45 | 1.05–2.01 | 0.03 |
BRAF mutation | 19/175 (11) | 9/225 (4) | 2.92 | 1.29–6.63 | 0.01 |
FBXW7 mutation | 8/175 (5) | 2/225 (1) | 5.34 | 1.12–25.48 | 0.04 |
NRAS mutation | 9/175 (5) | 1/225 (0.4) | 12.14 | 1.52–96.79 | 0.02 |
XPO1 mutation | 17/175 (10) | 9/225 (4) | 2.58 | 1.12–5.94 | 0.03 |
B. Univariate analysis: patients with a known cause of death and gene mutation data (n = 400) | |||||
11q deletion | 47/162 (29) | 40/209 (19) | 1.73 | 1.06–2.80 | 0.03 |
BRAF mutation | 19/175 (11) | 9/225 (4) | 2.92 | 1.29–6.63 | 0.01 |
FBXW7 mutation | 8/175 (5) | 2/225 (1) | 5.34 | 1.12–25.48 | 0.04 |
NRAS mutation | 9/175 (5) | 1/225 (0.4) | 12.14 | 1.52–96.79 | 0.02 |
XPO1 mutation | 17/175 (10) | 9/225 (4) | 2.58 | 1.12–5.94 | 0.03 |
C. Multivariate analysis: patients with a known cause of death and gene mutation data (n = 400) | |||||
11q deletion | 1.79 | 1.09–2.94 | 0.02 | ||
BRAF mutation | 3.22 | 1.33–7.80 | 0.01 | ||
NRAS mutation | 10.78 | 1.31–88.43 | 0.03 | ||
XPO1 mutation | 2.49 | 1.01–6.12 | 0.05 | ||
