Fig. 1: Dactinomycin can induce CR/CRi in NPM1-mutated AML patients. | Leukemia

Fig. 1: Dactinomycin can induce CR/CRi in NPM1-mutated AML patients.

From: Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Fig. 1

A Schematic representation of the study protocol. B Bone marrow biopsies of patient UPN006 before and after induction. Left panels are stained with hematoxylin and eosin (H/E), while right panels are stained with an anti-NPM1 (tNPM1), which recognizes both mutant and wild-type NPM1 (APAAP immunostaining, original magnification ×400). C Monitoring of NPM1mut transcripts by reverse-transcriptase real-time quantitative PCR in 8 out of 10 patients included in the protocol. Data are expressed as percentage of NPM1mut/ABL transcripts. Allo-HSCT, allogeneic hematopoietic stem cell transplant; R relapse, T transplant, Resp. responders, Non-resp. nonresponders.

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