Fig. 1: JunB expression correlates with expression profiles of angiogenic factors in MM cell line and primary cells.

A Correlation of JunB and angiogenic factor (AF) expression in primary samples of NDMM patients. Data analyses of samples within the GSE6477 dataset of NDMM patients indicate a statistically significant association for JunB with VEGF, VEGFB, and IGF1 but not with PIGF [26]. The Pearson correlation coefficient was calculated to evaluate the correlation between JunB and indicated AFs. The minimal level of significance was p < 0.05. B Heatmap of mRNA expression values (log2 and Z-score scaled across genes) for the indicated genes in MM cell line cells was obtained from data extracted from the Cancer Cell Line Encyclopedia (CCLE) database. The Pearson correlation coefficient was calculated to evaluate the correlation between JunB and indicated AFs. The minimal level of significance was p < 0.05. C Correlation of JunB and AF expression differs in the GSE2658 dataset of NDMM patients dependent on the molecular risk group. Heatmap of r values calculated on samples with known molecular information obtained from the GSE2658 dataset [26]. HYperdiploid (HY) group 4, Low Bone disease (LB) group 2, CD1 group 5, CD2 group 6, PRoliferation (PR) group 1, MMSET (MS) group 3, MAF/MAFB (MF) group 7. D Correlation of JunB and AF expression differs dependent on the number of 1q21 copies. Heatmap of r values calculated on samples with known molecular information obtained from the GSE2658 dataset [24] of NDMM patients.