Table 2 Comparison of prognostic/predictive models.
From: NK-/T-cell lymphomas
Model | Prognostic factors (points) | Definition (points) | Development/validation era | Accuracya | ||
---|---|---|---|---|---|---|
Anthracycline | No anthracycline | C-statistic | AUC for 5-year survival | |||
IPI | Age >60 years (1); Increased LDH (1); PS ≥ 2 (1); Stage-III/IV (1); Extra-nodal disease ≥2 (1) | Low-risk (0–1) Intermediate low-risk (2) Intermediate high-risk (3) High-risk (≥4) | Development | – | 0.62 | 0.61 |
KPI | B-symptoms (1); Stage-III/IV (1); Increased LDH (1); Regional lymph node involvement (1) | Group 1 (0) Group 2 (1) Group 3 (2) Group 4 (≥3) | Development | Validation | 0.64 | 0.68 |
PINK | Age >60 years (1); Stage-III/IV (1); Distant lymph node involvement (1); Non-nasal disease (1) | Low-risk (0) Intermediate-risk (1) High-risk (≥2) | – | Development and validation | 0.61 | 0.63 |
NRI | Age >60 years (1); Stage-II (1); Stage-III/IV (2); PS ≥ 2 (1); Increased LDH (1); With PTI (1) | Low-risk (0) Intermediate low-risk (1) Intermediate high-risk (2) High-risk (3) Very high-risk (≥4) | Development | Validation | 0.70 | 0.72 |