Table 3 Cox regression models on overall survival and cumulative incidence of relapse for all patients and according to IS groups.

From: Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results

 

All patients

JMDsole

JMD/TKD1

TKD1sole

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Overall survival

n = 356

n = 194

n = 91

n = 71

TKD1sole (vs JMDsole)

1.61 (1.10–2.34)

0.014

      

TKD1sole (vs JMD/TKD1)

2.17 (1.29–3.67)

0.004

      

JMDsole (vs JMD/TKD1)

1.35 (0.86–2.12)

0.189

      

Midostaurin treatment

0.79 (0.59–1.06)

0.120

0.56 (0.37–0.84)

0.005

0.94 (0.52–1.71)

0.835

1.12 (0.56–2.24)

0.741

FLT3-ITD cAR (log2)

1.07 (0.99–1.15)

0.093

1.18 (1.05–1.33)

0.006

1.12 (0.93–1.34)

0.239

0.97 (0.87–1.09)

0.641

No of ITDs

1.13 (0.99–1.28)

0.076

1.29 (1.04–1.60)

0.022

1.10 (0.91–1.32)

0.317

1.01 (0.55–1.85)

0.983

WBC (log2)

1.12 (1.03–1.23)

0.010

1.02 (0.91–1.14)

0.767

1.09 (0.89–1.32)

0.408

1.38 (1.09–1.75)

0.008

Age (10–year difference)

1.17 (1.02–1.34)

0.029

1.24 (1.03–1.51)

0.024

0.92 (0.68–1.23)

0.557

1.28 (0.96–1.70)

0.096

NPM1 mutation

0.58 (0.43–0.78)

<0.001

0.47 (0.31–0.72)

<0.001

0.69 (0.36–1.30)

0.248

0.57 (0.28–1.15)

0.115

HCT in CR1

0.46 (0.30–0.70)

<0.001

0.65 (0.38–1.10)

0.111

0.17 (0.04–0.74)

0.018

0.28 (0.12–0.68)

0.005

Cumulative Incidence of Relapse

n = 253

n = 140

n = 66

n = 47

TKD1sole (vs JMDsole)

2.20 (1.34–3.59)

0.002

      

TKD1sole (vs JMD/TKD1)

1.66 (0.90–3.08)

0.107

      

JMDsole (vs JMD/TKD1)

0.76 (0.41–1.30)

0.312

      

Midostaurin treatment

0.80 (0.56–1.15)

0.222

0.57 (0.34–0.96)

0.036

0.87 (0.45–1.69)

0.686

1.93 (0.75–4.97)

0.171

FLT3-ITD cAR (log2)

1.16 (1.04–1.29)

0.007

1.45 (1.21–1.73)

<0.001

1.05 (0.83–1.32)

0.649

1.02 (0.88–1.21)

0.776

No of ITDs

1.05 (0.89–1.24)

0.538

1.43 (1.02–2.02)

0.040

1.02 (0.83–1.26)

0.846

0.69 (0.30–1.58)

0.379

WBC (log2)

1.18 (1.06–1.31)

0.003

1.16 (0.99–1.35)

0.062

1.18 (0.95–1.47)

0.139

1.33 (1.04–1.70)

0.021

Age (10-year difference)

1.00 (0.84–1.18)

0.982

1.04 (0.81–1.33)

0.766

0.98 (0.70–1.37)

0.908

1.02 (0.70–1.50)

0.904

NPM1 mutation

0.67 (0.45–0.98)

0.037

0.46(0.27–0.78)

0.004

0.81(0.41–1.62)

0.555

0.91(0.30–2.47)

0.858

HCT in CR1

0.42 (0.26–0.69)

<0.001

0.40(0.20–0.80)

0.010

0.68(0.27–1.70)

0.409

0.19(0.06–0.57)

0.003

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