Table 4 Summary of H3B-8800 plasma PK parameters on Day 4 following once-daily dose regiments.
Statistical summary of plasma PK parameters on Day 1 | |||||
|---|---|---|---|---|---|
Dose (mg) | n | Tmax (h) | Cmax (µg/L) | AUC0-24 (µg*h/L) | t1/2 (h) |
1.0 | 3 | 2 (0.5–2) | 0.835 (90.8) | 4.89 (38.6) | 5.1 (65.3) |
2.0 | 7 | 2 (0.5–6) | 1.09 (64.4) | 8.39 (42.0) | 5.4 (31.9) |
3.5 | 6 | 1.5 (0.5–2) | 2.78 (82.4) | 15.6 (52.5) | 5.4 (15.2) |
5.0 | 9 | 1 (0.5–4) | 3.94 (30.0) | 24.5 (24.2) | 5.8 (27.1) |
7.0 | 19 | 1 (0.5–4) | 9.61 (69.7) | 39.4 (38.7) | 5.3 (23.8) |
10 | 7 | 1 (0.5–2) | 12.7 (36.3) | 51.0 (20.5) | 5.5 (14.2) |
12 | 5 | 2 (1–2) | 12.2 (37.4) | 64.7 (33.4) | 5.4 (17.3) |
14 | 10 | 1 (0.5–2) | 25.6 (63.9) | 108 (55.1) | 5.1 (21.8) |
20 | 8 | 0.75 (0.5–4) | 33.6 (49.2) | 142 (43.0) | 5.1 (10.3) |
30 | 4 | 1.25 (0.5–2) | 34.4 (44.7) | 159 (23.9) | 5.3 (10.2) |
40 | 6 | 0.5 (0.5–1) | 73.3 (85.8) | 265 (61.5) | 4.5 (17.2) |
