Table 3 PRS and association with MBL subtypes and CLL among individuals of European ancestry.

From: Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans

PRSb

Controlsc

LC-MBL

HC-MBL

CLL

LC-MBL vs controls

HC-MBL vs Controls

CLL vs Controls

N = 2631

N = 396

N = 164

N = 696

N

%

N

%

N

%

N

%

ORa

95% CI

P

ORa

95% CI

P

ORa

95% CI

P

Q1 [4.32, 6.80)

597

22%

41

10%

9

6%

35

5%

0.51

0.34–0.76

0.001

0.33

0.15–0.70

0.004

0.31

0.21–0.46

1.0 × 10−8

Q2 [6.80, 7.32)

528

20%

62

16%

28

17%

71

10%

0.81

0.57–1.17

0.27

1.05

0.61–1.82

0.85

0.65

0.47–0.90

0.01

Q3 [7.32, 7.77)

553

21%

76

19%

27

16%

112

16%

1

Reference

1

Reference

1

Reference

Q4 [7.77, 8.28)

463

18%

82

21%

28

17%

142

20%

1.33

0.95–1.88

0.1

1.31

0.76–2.26

0.34

1.56

1.17–2.08

0.002

Q5 [8.28, 11.31)

490

19%

135

34%

72

44%

336

49%

2.10

1.53–2.88

4.0 × 10−6

3.13

1.97–4.98

1.0 × 10−6

3.49

2.70–4.51

1.2 × 10−21

Continuous

        

1.75

1.55–1.98

7.5 × 10−19

2.14

1.80–2.56

3.9 × 10−17

2.53

2.27–2.81

4.0 × 10−63

Continuous unweighted

        

1.14

1.11–1.17

1.3 × 10−20

1.19

1.14–1.23

1.9 × 10−17

1.23

1.20–1.26

4.1 × 10−65

PRS (median)

7.46

 

7.84

 

8.05

 

8.24

          

c-statistic

        

0.72

0.70–0.75

 

0.73

0.69–0.77

 

0.77

0.75–0.79

 

c-statistic unweighted

        

0.72

0.70–0.75

 

0.725

0.69–0.77

 

0.775

0.76–0.79

 
  1. CI confidence interval, CLL Chronic lymphocytic leukemia, HC high-count, LC low-count, MBL Monoclonal B-cell lymphocytosis, OR odds ratio, PRS polygenic risk score, Q quintile.
  2. aAdjusted for age and sex.
  3. bQuintiles based on 7983 controls.
  4. cThese controls were screened negative for MBL.
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