Fig. 4: CXCR4 hyperactivation does not accelerate MYC-driven B-cell lymphoma.
From: CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness
a Outline of breeding scheme of CXCR4C1013G and Eµ-Myc mice to generate double-transgenic Eµ-Myc;CXCR4C1013G mice. b Spleen weight of 1-month-old animals of genotypes as indicated (WT, n = 9; CXCR4C1013G, n = 8; Eµ-Myc n = 12; Eµ-Myc;CXCR4C1013G, n = 6). c Representative images of H&E and immunohistochemistry of 1-month-old Eµ-Myc and Eµ-Myc;CXCR4C1013G mice (scale bars: overview = 1 mm, detailed images: 20 µm). d Spleen weight of Eµ-Myc (n = 9) and Eµ-Myc;CXCR4C1013G (n = 13) mice with manifest lymphoma. e Bone marrow cell count of Eµ-Myc (n = 5) and Eµ-Myc;CXCR4C1013G (n = 7) mice with manifest lymphoma. f Kaplan–Meier survival curves of the indicated cohorts of mice (Eµ-Myc, n = 15; Eµ-Myc;CXCR4C1013G, n = 17). Median survival and P value of logrank (Mantel–Cox) test are shown. g Representative images of H&E and immunohistochemistry of Eµ-Myc and Eµ-Myc;CXCR4C1013G mice with manifest lymphoma (scale bars spleen: overview = 1 mm, detailed images: 20 µm, scale bars liver: overview = 1 mm, detailed images = 20 µm). Statistical analyses were performed with Student’s t test or one-way ANOVA with Tukey correction for multiple comparisons, *P < 0.05, **P < 0.01, ***P < 0.001. Error bars indicate standard deviation (SD).
