Fig. 1: AML exhibits high USP15 expression compared to other tumor types and normal hematopoietic cells. | Leukemia

Fig. 1: AML exhibits high USP15 expression compared to other tumor types and normal hematopoietic cells.

From: The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

Fig. 1

A RSEM expression values for USP15 mRNA in the TCGA PanCancer study. LAML in red = acute myeloid leukemia. B Normalized RPKM values for USP15 RNA expression in healthy control CD34+ samples and AML patient samples from the BEAT-AML dataset. *P < 0.05. C Immunoblot for USP15 and vinculin (loading control) on lysates generated from healthy CD34+ control cells and the indicated human AML cell lines. Vinculin expression was variable among the different cell types. Shown are representative data from 2 replicate experiments. D Relative expression of USP15 protein expression (normalized to VINCULIN) was determined by densitometry performed in ImageJ software. Shown are the normalized values from panel (C).

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