Fig. 3: Potential expression of a functional complosome in normal HSPCs as a challenging topic for further investigations. | Leukemia

Fig. 3: Potential expression of a functional complosome in normal HSPCs as a challenging topic for further investigations.

From: Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship

Fig. 3

The expression of ComC proteins and certain receptors in T lymphocytes that regulate their activity and metabolic state have been named the “complosome”. Our preliminary results indicate that the complosome may also be operational in normal murine and human HSPCs. The figure shows potential elements of the complosome that could operate in HSPCs, similarly as the elements described by others for T cells. The presence of CD46 on the surface of murine cells is still under debate.

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