Fig. 1: Impact of early relapse on overall survival.

A Kaplan–Meier curve showing the impact of early (≤24 months) vs late (>24 months) relapse on OS from 1st line. Patients with early relapse had a significantly poorer survival than the late relapses—median OS 71 months (95% CI 53.53–88.46 months) vs not reached (p < 0.005). 100%, 100% and 80% of LR patients were alive at the end of 1, 2 & 5 years, respectively. B Kaplan–Meier curve showing the impact of early (≤24 months) vs late (>24 months) relapse on OS from 1st line, stratified by the haematologic response (CR & VGPR) after 1st line. Patients who relapsed early had a significantly poorer survival than those who relapsed late, irrespective of their initial haematologic response (p < 0.005). There was no significant difference in survival between CR+ early response & VGPR+ early response- median OS 61 months vs 64 months (95% CI 53. 91–74.08 months), p = 0.727. Similarly, there was no significant difference in survival between CR + late response and VGPR + late response- median OS 109 months vs not reached, p = 0.505. VGPR + late response had a superior survival than CR + early response- median OS not reached vs 61 months, p < 0.005. Of, 100%, 100% and 80% of VGPR + late response were alive at the end of 1, 2 & 5 years, respectively.