Fig. 1: BCP-ALL cell lines present heterogeneous sensitivity to cell death induced by BH3-mimetics.
From: Synergistic activity of combined inhibition of anti-apoptotic molecules in B-cell precursor ALL
BCP-ALL cell lines were exposed for 48 hours to increasing concentrations (2.5, 5, 25, 50, 250, 500, and 2500 nM) of (A) venetoclax, (B) S63845 or (C) A-1331852 before analysis of cell death by propidium iodide staining and flowcytometry. N = 3 independent experiments in triplicates. D–F Association of the EC50 values of venetoclax, S63845 and A-1331852 of all cell lines. Spearman correlation; r, correlation coefficient; p, significance. (G) 3D scatter plot of the EC50 values of the three inhibitors. The colors of the symbols represent the half maximal effective concentration (EC50) values of venetoclax as indicated in the legend and the sizes indicate the EC50 values of S63845. H Scatter plot of EC50 values of the three BH3-mimetics with individual data points of single cell lines and medians (lines). Kruskal-Wallis test; p, significance.
