Table 1 Secondary hCD45-populated PDX transplants in NSG mice.

From: Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL

Treatment group

Input PDX cells (n)

Penetrancea

hCD45 + cells in selected mice at day 39 (%)

Median survival time (days)

BM

Spleen

Vehicle

0.25 × 104

6/8

84.50

75.50

38.0

1.00 × 106

8/8

95.70

82.57

36.5

ARV-825

0.25 × 104

5/8

39.30

55.60

58.0

1.00 × 106

7/8

51.43

53.40

50.0

Treatment group

Input

Mice T-ALL cells (n)

Penetranceb

Vehicle

5 × 105

3/6

1.00 × 106

8/8

ARV-825

5 × 105

0/6

1.00 × 106

6/8

  1. Secondary transplantation of mice -T-ALL- in 5 weeks 4.5 Gy irradiated black mice.
  2. aNumber of mice with T-ALL/number of implanted mice at day 22.
  3. bNumber of mice with T-ALL/number of implanted mice at day 128.
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