Fig. 4: Targeting either extracellular epitope of CS1 by CS1-CAR-T is effective. | Leukemia

Fig. 4: Targeting either extracellular epitope of CS1 by CS1-CAR-T is effective.

From: CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+CS1 expressing CAR-T cells

Fig. 4

A Flow cytometry of CD4 and CD8 populations. B Killing of MM.1S-CG targets by Luc90-CAR-T and HuLuc63-CAR-T assessed using 51chromium assays. C BLI of both CS1-CAR-Ts and (D) Kaplan–Meier survival analysis. Some mice were censored since they had no BLI signal but died of an infection.

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