Table 8 Cytogenetic and molecular abnormalities defining acute myeloid leukaemia, myelodysplasia-related.

From: The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Defining cytogenetic abnormalities

 Complex karyotype (≥3 abnormalities)

 5q deletion or loss of 5q due to unbalanced translocation

 Monosomy 7, 7q deletion, or loss of 7q due to unbalanced translocation

 11q deletion

 12p deletion or loss of 12p due to unbalanced translocation

 Monosomy 13 or 13q deletion

 17p deletion or loss of 17p due to unbalanced translocation

 Isochromosome 17q

 idic(X)(q13)

Defining somatic mutations

 ASXL1

 BCOR

 EZH2

 SF3B1

 SRSF2

 STAG2

 U2AF1

 ZRSR2

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