Fig. 1: STAT6 mutations are associated with activated IL-4 signaling in human FL.

A Lolliplot of STAT6 mutations in 258 human FL biopsies. B Unsupervised hierarchical clustering of gene expression data from 106 human FL, annotated for STAT6 genotype. C Same data used for gene set enrichment analysis (GSEA) for established IL-4 signatures comparing STAT6^WT and STAT6^MUT. D Volcano plot of differentially expressed genes between STAT6^WT and STAT6^MUT FL (N = 106, log2FC = ±0.65, p value = 0.05). E FCER2 (CD23) gene expression in human FL with wild type STAT6 (STAT6^WT) vs any STAT6 mutation (STAT6^MUT) vs STAT6 mutations at position D419 (STAT6^D419). F Representative immunohistochemistry (IHC) stains for CD23 and pSTAT6 in human FL with STAT6^WT (left) and STAT6^MUT (STAT6^D419G, right).