Fig. 4: COX-2 expression in healthy controls’ and in AA patients’ bone marrow samples.
From: Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia
A UMAP representation of single-cell RNA-sequencing profiles from 15 untreated AA patients and 2 healthy bone marrow samples and (data reanalyzed from Zhu et al. [33]), colored by cell cluster. B COX-2 (PTGS2) expression over the cell phenotypes. C Differential expression of COX-2 (PTGS2) in GMP/CMP cells from untreated AA patients and healthy donors. p value was calculated with a two-sided Mann–Whitney test. EBM eosinophil, basophil, and mastocyte progenitor, GMP/CMP granulocyte-monocyte precursor/common myeloid precursor, CLP common lymphoid precursor, L-MPP lymphoid-primed multipotent progenitor, MPP/HSC multipotent progenitor/hematopoietic stem cell.
