Table 2 Logistic regression analysis of the clinical parameters (adult IAA patients n = 276).

From: Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia

 

aCOX-2 Ab negative

aCOX-2 Ab positive

OR (univariable)

OR (multivariable)

OR (multivariable. MI)

HLA-DRB1*15:01

     

 Absent

115 (71.4)

18 (18.0)

–

–

–

 Present

46 (28.6)

82 (82.0)

11.39 (6.29–21.56. p < 0.001)

11.34 (3.55–43.47. p < 0.001)

14.96 (6.40–34.98. p < 0.001)

Gender

     

 Female

82 (48.5)

65 (60.7)

–

–

–

 Male

87 (51.5)

42 (39.3)

0.61 (0.37–0.99. p = 0.048)

1.23 (0.33–4.80. p = 0.760)

0.77 (0.34–1.72. p = 0.516)

Age at dg (years)

     

 Mean (SD)

38.9 (17.6)

61.4 (13.7)

1.08 (1.06–1.10. p < 0.001)

1.52 (1.22–1.98. p = 0.001)

1.34 (1.16–1.55. p < 0.001)

Age at dg2

     

 Mean (SD)

1821.9 (1636.7)

3956.6 (1612.1)

1.00 (1.00–1.00. p < 0.001)

1.00 (0.99–1.00. p = 0.006)

1.00 (1.00–1.00. p = 0.004)

PNH clone

     

 Absent

78 (53.4)

41 (42.3)

–

–

–

 Present

68 (46.6)

56 (57.7)

1.57 (0.94–2.64. p = 0.089)

1.02 (0.26–3.84. p = 0.981)

1.18 (0.51–2.73. p = 0.698)

Severity

     

 Moderate

41 (26.5)

28 (28.0)

–

–

–

 Severe

101 (65.2)

61 (61.0)

0.88 (0.50–1.58. p = 0.676)

1.92 (0.27–15.57. p = 0.523)

1.17 (0.37–3.68. p = 0.782)

 Very severe

13 (8.4)

11 (11.0)

1.24 (0.48–3.17. p = 0.654)

2.09 (0.11–43.76. p = 0.624)

1.49 (0.26–8.58. p = 0.657)

Hb at dg (g/dl)

     

 Mean (SD)

8.9 (2.1)

9.5 (10.1)

1.02 (0.98–1.09. p = 0.454)

1.36 (0.93–2.05. p = 0.122)

1.08 (0.90–1.29. p = 0.412)

WBC at dg (109/l)

     

 Mean (SD)

2.4 (1.5)

2.5 (1.3)

1.05 (0.89–1.25. p = 0.536)

2.46 (0.83–7.64. p = 0.103)

1.18 (0.59–2.38. p = 0.637)

Plt at dg (109/l)

     

 Mean (SD)

40.8 (46.4)

21.6 (16.8)

0.97 (0.96–0.98. p < 0.001)

0.98 (0.94–1.01. p = 0.219)

1.34 (1.16–1.55. p < 0.001)

ANC at dg (109/l)

     

 Mean (SD)

0.9 (1.0)

0.9 (0.7)

0.90 (0.66–1.20. p = 0.499)

0.28 (0.06–1.13. p = 0.077)

0.64 (0.26–1.59. p = 0.336)

ALC at dg (109/l)

     

 Mean (SD)

1.2 (0.8)

1.4 (0.7)

1.37 (0.94–2.00. p = 0.102)

1.08 (0.31–3.82. p = 0.901)

0.99 (0.38–2.55. p = 0.980)

  1. Logistic regression analysis for adult (>18 years old) IAA patients. For categorical variables numbers of patients together with the proportion of patients from aCOX-2 Ab negative and positive cohorts are reported. For continuous variables mean values together with standard deviations (SD) are reported.
  2. Dg diagnosis, PNH paroxysmal nocturnal hemoglobinuria, Hb hemoglobin, WBC white blood cells, Plt platelets, ANC absolute neutrophil counts, ALC absolute lymphocyte counts, SD standard deviation, OR odds ratio, MI multiple imputation.
  3. Statistically significant p-values are in bold.
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