Fig. 1: AID−/−/Eμ-TCL1 mice died significantly earlier than Eμ-TCL1 mice and had increased GL7+ activated B cells in the spleens.
From: Loss of AID exacerbates the malignant progression of CLL
A Kaplan-Meier survival analysis of Eμ-TCL1 and AID−/−/Eμ-TCL1 mice. B, C Kaplan–Meier survival analysis of female (B) and male (C) Eμ-TCL1 and AID−/−/Eμ-TCL1 mice. D–I Quantification of CD19+ B cell lineage cells (D), B cells (E), CLL cells (F), T cells (G), monocytes (H), and granulocytes (I) in the peripheral blood of Eμ-TCL1 (n = 11) and AID−/−/Eμ-TCL1 (n = 12 at 2 and 4 months and n = 11 at 6 months) mice at 2, 4, and 6 months of age by flow cytometry. J–L Quantification of CD19+ B cell lineage cells (J), B cells (K), and CLL cells (L) in the spleens of 6-month-old Eμ-TCL1 (n = 21) and AID−/−/Eμ-TCL1 (n = 18) mice by flow cytometry. M–O Quantification of follicular B cells (M), marginal zone B cells (N), and GL7+ activated B cells (O) in the spleens of 6-month-old Eμ-TCL1 (n = 11) and AID−/−/Eμ-TCL1 (n = 11) mice by flow cytometry.
