Table 1 Frequencies of somatic mutations at baseline.
Type of somatic mutation | Frequency | ||||
|---|---|---|---|---|---|
Non HI-P (N = 45) | HI-P (N = 32) | ||||
Visit | Mutation | N | % | N | % |
Screening | ≥1 mutation | 35 | 77.8 | 25 | 78.1 |
≥2 mutations | 22 | 48.9 | 18 | 56.3 | |
no mutations | 3 | 6.7 | 2 | 6.3 | |
ABL1 | 0 | 0.0 | 1 | 3.1 | |
ASXL1 | 7 | 15.6 | 2 | 6.3 | |
BCOR | 2 | 4.4 | 1 | 3.1 | |
BRAF | 0 | 0.0 | 1 | 3.1 | |
CBL | 2 | 4.4 | 1 | 3.1 | |
CBLB | 0 | 0.0 | 1 | 3.1 | |
CEBPA | 0 | 0.0 | 2 | 6.3 | |
CUX1 | 1 | 2.2 | 1 | 3.1 | |
DNMT3A | 9 | 20.0 | 4 | 12.5 | |
EZH2 | 5 | 11.1 | 2 | 6.3 | |
FLT3 | 0 | 0.0 | 1 | 3.1 | |
GNAS | 2 | 4.4 | 0 | 0.0 | |
IDH1 | 1 | 2.2 | 0 | 0.0 | |
IDH2 | 1 | 2.2 | 0 | 0.0 | |
KMT2A | 0 | 0.0 | 2 | 6.3 | |
KRAS | 1 | 2.2 | 1 | 3.1 | |
MPL | 1 | 2.2 | 0 | 0.0 | |
MYC | 1 | 2.2 | 0 | 0.0 | |
NF1 | 1 | 2.2 | 1 | 3.1 | |
NPM1 | 1 | 2.2 | 1 | 3.1 | |
NOTCH1 | 2 | 4.4 | 1 | 3.1 | |
NRAS | 2 | 4.4 | 1 | 3.1 | |
PHF6 | 1 | 2.2 | 1 | 3.1 | |
PPM1D | 0 | 0.0 | 1 | 3.1 | |
RAD21 | 0 | 0.0 | 1 | 3.1 | |
RUNX1 | 7 | 15.6 | 7 | 21.9 | |
SETBP1 | 0 | 0.0 | 1 | 3.1 | |
SF3B1 | 1 | 2.2 | 2 | 6.3 | |
SH2B3 | 1 | 2.2 | 0 | 0.0 | |
SMC3 | 1 | 2.2 | 0 | 0.0 | |
SRSF2 | 7 | 15.6 | 13 | 40.6 | |
STAG2 | 3 | 6.7 | 0 | 0.0 | |
TET2 | 11 | 24.4 | 10 | 31.3 | |
TP53 | 2 | 4.4 | 4 | 12.5 | |
U2AF1 | 6 | 13.3 | 3 | 9.4 | |
U2AF2 | 1 | 2.2 | 0 | 0.0 | |
WT1 | 1 | 2.2 | 0 | 0.0 | |
ZRSR2 | 1 | 2.2 | 2 | 6.3 | |
