Fig. 2: Genetic events associated with chromosome instability in T-ALL with chromothripsis. | Leukemia

Fig. 2: Genetic events associated with chromosome instability in T-ALL with chromothripsis.

From: Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults

Fig. 2

RNA microarray showed that: a the levels of MYCN expression were significantly higher in chromothripsis positive (cth+) (=11 cases) than chromothripsis negative (cth−) (=22 cases) cases (FDR p value 0,0215) (Mann–Whitney test, p = 0.0002) and that; b RGCC expression was significantly lower in cth+ (=11) than cth− (=22) cases (FDR p value 0,0254) (Mann–Whitney test, p < 0.0001). The expression of MYCN and RGCC was indicated as log signal. c The heat-map reports on the types and distribution of alterations affecting DNA repair/chromosome stability genes, in the 12 cth+ T-ALL cases (patient numbers refer to Table 1). Bar graphs, i.e., top left and bottom right, respectively indicate the number of genomic events for each case and the number of events for each gene. Loss: monoallelic deletion.

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