Fig. 2: The spleen contributes to disease progression.
From: Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance
BL/6 mice were splenectomized or sham-operated 14 days prior to CML induction. A Numbers of BCR-ABL1-GFP+ granulocytes/µL blood, measured at day 14 and 18 after CML induction. B Kaplan–Meier survival curve of primary transplanted, non-irradiated, splenectomized or sham-operated BL/6 recipients. Pooled data from three independent experiments with n = 11–15 mice per group are shown. C–G Absolute numbers of different leukemic cell subsets in the BM of splenectomized and sham-operated animals at day 18 after CML induction. Pooled data from 3 independent experiments with n = 13 mice per group are shown. Data are displayed as mean ± SEM. Statistics: 2-way ANOVA (A), log-rank test (B), unpaired student’s t test (C–G).
