Fig. 7: LSCs co-localize with macrophages in human CML spleens.
From: Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance
A Mean distance between CD68+ macrophages and CD34+ human stem/progenitor cells or CD68−CD34− cells in 4 CML patients. B Representative immunohistochemical staining (patient 1) for CD68 (brown) and CD34 (red). Stem/progenitor cells (CD34+ non-vascular cells with a nuclear morphology compatible with immature cells (large nuclei, open chromatin)) are annotated with yellow circles. Data are displayed as mean ± SEM. Statistics: Paired student’s t test.
