Table 2 Re-stratification matrix of the number of MDS patients classified in each of the WHO 2016 classification (column) and each of the WHO 2022 classification (row).

From: Comparison of the revised 4th (2016) and 5th (2022) editions of the World Health Organization classification of myelodysplastic neoplasms

WHO-2016, n

MDS-5q

MDS-RS-SLD

MDS-RS-MLD

MDS-SLD

MDS-MLD

MDS-EB1

MDS-EB2

MDS-U

Number of patients, n (%)

WHO-2022, n

MDS-5q

11

0

0

0

0

0

0

0

11(1.3)

MDS-SF3B1

0

21

24

3

21

0

0

1

70 (8.6)

MDS-biTP53

1

1

0

1

14

10

24

2

53 (6.5)

MDS-LB

0

0

0

34

254

0

0

5

293 (36)

MDS-h

0

0

0

11

67

0

0

2

80 (9.8)

MDS-IB1

0

0

0

0

0

161

0

0

161 (19.8)

MDS-IB2

0

0

0

0

0

0

103

0

103 (12.7)

MDS-f

0

0

0

0

0

20

22

0

42 (5.2)

Number of patients, n (%)

12 (1.5)

22 (2.7)

24 (3.0)

49 (6)

356 (43.8)

191 (23.5)

149 (18.3)

10 (1.2)

813

  1. WHO World Health Organization, MDS myelodysplastic syndromes(neoplasms), MDS-U MDS unclassifiable, SLD single lineage dysplasia, MLD multilineage dysplasia, RS-SLD ring sideroblasts with SLD, RS-MLD ring sideroblasts with MLD, EB1/2 excess blasts type 1/2, 5q- isolated 5q deletion, biTP53 biallelic TP53 inactivation, LB low blasts, MDS-SF3B1 MDS with low blasts and SF3B1 mutation, MDS-h MDS hypoplastic, IB1/2: increased blasts type1/2, MDS-f MDS with fibrosis.