Table 3 Frequency of somatic mutations occurring in Waldenström’s macroglobulinemia as a basis for the design of a next-generation sequencing panel.

From: Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

 

Hunter et al. [18]

Poulain et al. [57]

Varettoni et al. [30]

Jiménez et al. [19]

All

Gene

N = 30

N = 98

N = 62

N = 47

N = 237

MYD88

27

77

53

46

86%

CXCR4

27

24

14

17

35%

KTM2D

2

NA

15

NA

18%

TP53

2

9

6

1

7.6%

CD79A/B

2

9

2

4

7.2%

ARID1A

5

NA

3

2

7.2%

NOTCH2

1

NA

3

NA

4.3%

PRDM1

0

NA

4

NA

4.3%

HIST1H1E

0

NA

NA

3

3.8%

MYBBP1A

2

NA

0

2

2.9%

TRAF3

1

NA

1

2

2.9%

TRAF2

1

NA

NA

1

2.6%

RAG2

1

NA

NA

1

2.6%

HIST1H1B

0

NA

NA

1

1.3%

HIST1H1D

0

NA

NA

1

1.3%

  1. NA not applicable.
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