Table 3 Distribution of key copy number alterations by genomic subtype.
PAX5alt | DUX4-r | CRLF2-r/JAK2-r | ZNF384-r | ABL-class | ETV6::RUNX1-like | |
|---|---|---|---|---|---|---|
N = 91 | N = 80 | N = 53 | N = 37 | N = 25 | N = 21 | |
IKZF1 deletion | ||||||
No | 54 (70%) | 55 (71%) | 16 (46%) | 28 (93%) † | 9 (60%) | 10 (59%) |
Yes | 23 (30%) * | 22 (29%) | 19 (54%) ‡ | 2 (7%) | 6 (40%) | 7 (41%) |
PAX5 deletion | ||||||
No | 20 (26%) | 70 (91%) ‡ | 20 (57%) | 29 (97%) ‡ | 10 (67%) | 12 (71%) |
Yes | 57 (74%) ‡ | 7 (9%) | 15 (43%) | 1 (3%) | 5 (33%) | 5 (29%) |
CDKN2A/B deletion | ||||||
No | 5 (6%) | 55 (71%) ‡ | 19 (54%) | 24 (80%) † | 11 (73%) | 15 (88) † |
Yes | 72 (94%) ‡ | 22 (29%) | 16 (46%) | 6 (20%) | 4 (27%) | 2 (12%) |
BTG1 deletion | ||||||
No | 75 (97%) | 76 (99%) | 28 (80%) | 28 (93%) | 12 (80%) | 14 (82%) |
Yes | 2 (3%) | 1 (1%) | 7 (20%) ‡ | 2 (7%) | 3 (20%) | 3 (18%) |
ETV6 deletion | ||||||
No | 64 (83%) | 71 (92%) † | 29 (83%) | 20 (67%) | 13 (87%) | 5 (29%) |
Yes | 13 (17%) | 6 (8%) | 6 (17%) | 10 (33%) | 2 (13%) | 12 (71%) ‡ |
EBF1 deletion | ||||||
No | 77 (100%) | 77 (100%) | 31 (89%) | 29 (97%) | 15 (100%) | 17 (100%) |
Yes | 0 (0%) | 0 (0%) | 4 (11%) ‡ | 1 (3%) | 0 (0%) | 0 (0%) |
RB1 deletion | ||||||
No | 74 (96%) | 77 (100%)† | 31 (89%) | 25 (83%) | 14 (93%) | 16 (94%) |
Yes | 3 (4%) | 0 (0%) | 4 (11%) | 5 (17%) | 1 (7%) | 1 (6%) |
IKZF1plus | ||||||
No | 54 (70%) | 76 (99%) ‡ | 20 (57%) | 29 (97%) | 11 (73%) | 15 (88%) |
Yes | 23 (30%) *‡ | 1 (1%) | 15 (43%) ‡ | 1 (3%) | 4 (27%) | 2 (12%) |
UKALL CNA profile | ||||||
GR | 5 (6%) | 40 (52%) ‡ | 0 (0%) | 20 (67%) ‡ | 7 (47%) | 7 (41%) |
IR/PR | 72 (94%) ‡ | 37 (48%) | 35 (100%) ‡ | 10 (33%) | 8 (53%) | 10 (59%) |
