Fig. 1: Overview of 1588 CLL cases carrying mutations in recurrently mutated genes.

A Oncoplot of detected gene mutations (in order of frequency), IGHV gene somatic hypermutation (SHM) status and chromosomal aberrations. B Relative distribution of recurrent gene mutations stratified by IGHV gene SHM status, ** denotes a p value <0.01, while *** represents a p value <0.001. C Co-occurence of recurrently mutated genes and chromosomal aberrations.