Fig. 2: Tumor-level phylogenetic trees for 10 HCLc tumors.
From: The genomic landscape and clonal evolutionary trajectory of classical hairy cell leukemia
Branch lengths are proportional to the number of SNVs within the mutation cluster and branch thickness (height of gray bar) is proportional to the CCF of the cluster. Mutations that have occurred before the most recent common ancestor (MRCA) are carried by all tumor cells and define the clonal cluster of mutations. Each branch is annotated with known and candidate mutational and copy number drivers identified in each sample (the order of the drivers displayed on the branches is arbitrary). The mutation clusters are named alphabetically. The phylogeny in HCL2 and HCL5 can only be linear and not branching (subclonal clusters B and C with respect to the clonal cluster A) according to the pigeonhole principle.
