Table 1 Criteria for bone marrow fibrosis grading.

From: Inhibition of ERK1/2 signaling prevents bone marrow fibrosis by reducing osteopontin plasma levels in a myelofibrosis mouse model

Grading

Description

MF-0

no reticulin fibers corresponding to normal bone marrow

MF-0.5

focal areas with a loose network of reticulin with many intersections alternated with areas with no reticulin fibers

MF-1

loose network of reticulin with many intersections evenly distributed over the entire length of the femurs

MF-1.5

focal areas with a diffuse and dense increase in reticulin with extensive intersections

MF-2

diffuse and dense increase in reticulin with extensive intersections evenly distributed over the entire length of the femurs, occasionally with only focal bundles of collagen and/or focal osteosclerosis

MF-3

diffuse and dense increase in reticulin with extensive intersections with coarse bundles of collagen, often associated with significant osteosclerosis