Fig. 3: PDLS transcriptome compared to MCL-2D. | Leukemia

Fig. 3: PDLS transcriptome compared to MCL-2D.

From: A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses

Fig. 3

A Volcano plot representing the differentially expressed genes (DEG) between MCL-PDLS after 7 days of culture to 2D-MCL culture with monocytes and cytokines. DEG were obtained by a paired (n = 4) DESeq2 analysis (FDR < 0.1 and absolute log2FC > 0.5). B Heatmap of DEG for the individual patients (n = 4). C Percentage of genes described in each pathway (as in Fig. 2) [12, 34] which are upregulated in the PDLS or in MCL-2D. D GSEA plots representing significantly enriched pathways (FDR < 0.05) in the PDLS compared to 2D-MCL. E Heatmaps of leading genes of the indicated gene sets in (D).

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