Fig. 6: Ibrutinib affects CD40 protein expression in a non-transcriptional manner. | Leukemia

Fig. 6: Ibrutinib affects CD40 protein expression in a non-transcriptional manner.

From: Ibrutinib sensitizes CLL cells to venetoclax by interrupting TLR9-induced CD40 upregulation and protein translation

Fig. 6

A, B Immunological detection of CD40 and CD95 in LN emigrants (CD5highCXCR4dim) compared to LN immigrants (CXCR4highCD5dim) of patient samples obtained at baseline and after two months ibrutinib treatment (N = 7). C CD40 mRNA expression levels were measured by real-time PCR in patient samples obtained at baseline and after two months ibrutinib treatment (N = 7). D Bcl-2 family member mRNA expression levels were measured by real-time PCR. Samples were normalized to HPRT (N = 6). Paired sample t-test was used for statistical analyses.

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