Fig. 2: Baseline biological features associated with UBTF-TDs.
From: UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia

A Mutational landscape of AML with UBTF-TD. Only genes with at least one mutation in one patient are shown. The full list of screened genes is given in the Supplementary Table 2. B BM blast infiltration and (C) WBC count according to UBTF and NPM1 status in AML patients aged 18–60 years. The black bars indicate the median values. (D) Associations among gene and cytogenetic abnormalities in AML patients aged 18–60 years. (E) BM blast infiltration, (F) WBC count and (G) BM morphology classification according to FLT3-ITD status in UBTF-TD AML. The FiLT3r algorithm was used for detection and precise quantification of FTL3-ITDs [23]. H BM morphology in patient #L171D0708G (FLT3-ITD with VAF < 5%) and (I) patient #L151D4757X (FLT3-ITD negative) showing characteristic dyserythropoiesis and blasts with rare Auer rods (red arrow). J BM morphology in patient #L221T6545N (FLT3-ITD with VAF > 70%) showing massive blast infiltration.