Table 1 Clinical, cytological, cytogenetic characteristics and outcome of RUNX1m/del and RUNX1wt children.
RUNX1m/del | RUNX1wt | P value | |
|---|---|---|---|
n = 29 (8%) | n = 357 (92%) | ||
Clinical data, n (%) | |||
Male gender | 14 (48%) | 196 (55%) | 0.56 |
Age at diagnosis | |||
≤2 years old | 2 (7%) | 79 (22%) | 0.06 |
Median age [min-max] | 11.2 [0.7–17.2] | 8.4 [0–18.6] | 0.07 |
CNS involvement | 3 (10%) | 57 (16%) | 0.60 |
White blood cells count at diagnosis | |||
>100 G/L | 4 (14%) | 57 (16%) | 0.62 |
Median count | 10.8 [1.7 –445] | 17.7 (0.4–575) | 0.20 |
Risk group | |||
Standard | 2 (7%) | 90 (25%) | |
Intermediate | 20 (69%) | 181 (51%) | ns |
Adverse | 6 (21%) | 84 (24%) | |
Cytogenetics, n (%) | |||
Normal | 10 (34%) | 90 (25%) | 0.28 |
CBF | 2 (7%) | 90 (25%) | 0.02 |
MLL | 0 | 78 (22%) | 0.002 |
−7/del7q | 5 (17%) | 28 (8%) | 0.09 |
Complex karyotype | 6 (21%) | 39 (11%) | 0.13 |
Missing | 1 (4%) | 2 (1%) | 0.21 |
FAB classification, n (%) | |||
M0 | 5 (17%) | 19 (5%) | 0.03 |
M1 | 8 (28%) | 54 (15%) | 0.11 |
M2 | 8 (28%) | 82 (23%) | 0.65 |
M4 | 3 (10%) | 76 (21%) | 0.23 |
M5 | 1 (3%) | 85 (24%) | 0.009 |
M6 | 2 (7%) | 9 (3%) | 0.20 |
M7 | 1 (3%) | 18 (5%) | 1 |
Unclassified + basophil | 1 (3%) | 9 (3%) | 0.55 |
Chloroma | 0 | 5 (1%) | 1 |
Outcome, n (%) | |||
Complete remission | 24 (83%) | 327 (92%) | 0.17 |
Relapse | 11 (38%) | 122 (34%) | 0.69 |
HSCT | 9 (31%) | 99 (28%) | 0.67 |
Death | 17 (59%) | 86 (24%) | <0.001 |
Survival, [CI 95%] | |||
5-years OS | 33.6% [18.6–60.8] | 75.7% [71.3–80.4] | <0.001 |
5-years EFS | 32.5% [16.8–62.8] | 61.4% [56.2–67.2] | 0.003 |
