Fig. 2: Histological Presentation Patterns of BPDCN. | Leukemia

Fig. 2: Histological Presentation Patterns of BPDCN.

From: Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies

Fig. 2

BPDCN involving the skin of a 14-year-old female. Staining with hematoxylin and eosin reveals a diffuse monotonous dermal-based infiltrate of medium-sized blastoid cells that spares the Grenz zone and epidermis and focally extends into the subcutaneous tissue (A, ×2; B, ×200). Occasional mitotic figures are present (C, ×500). Tumor cells are positive for CD4, CD56, and CD123 but negative for CD3, CD19, and myeloperoxidase (not shown). BPDCN involving the BM of a 16-year-old male. Staining with hematoxylin and eosin reveals an interstitial and diffuse infiltrate displacing hematopoietic elements (D, ×200;). A Wright-Giemsa–stained BM smear shows numerous blastic cells with irregular nuclear contours, immature chromatin, occasional small nucleoli, and variable light basophilic cytoplasm with occasional tail-like protrusions (E, ×1000). By immunohistochemistry, tumor cells are positive for TCF4/CD123 (F, ×500) and CD56 (G, ×500) but negative for CD3, CD19, and myeloperoxidase (not shown).

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