Table 1 Comparison of key characteristics in presentation and outcome between adult and pediatric patients with BPDCN.

From: Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies

Characteristic

Adult patients [123]

Pediatric and Adolescent Patients

Age (Years)

Median

66

10

Range

19–86

0.6–18

Sex (M:F)

 

4:1

1:1

Presentation

Skin+ Only

35%

25%

BM+

64%

75%

CNS+ During Therapy

 

33%

60%

Dead of Disease – Initial Therapy

 

66%

7%

HSCT at CR1

 

33%

20%

Overall Survival (Months)

Median

23

-

Mean

-

78.8

Range

0.9–158

1–132

  1. Summary statistics of adult patients from Pemmaraju et al. (2022).
  2. BM bone marrow disease, CNS central nervous system disease, HSCT hematopoietic stem cell transplant, CR1 relapse from first successful therapy.
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