Fig. 5: Haploinsufficient (HI) gene analysis of -7/del7q cases. | Leukemia

Fig. 5: Haploinsufficient (HI) gene analysis of -7/del7q cases.

From: Genomics of deletion 7 and 7q in myeloid neoplasm: from pathogenic culprits to potential synthetic lethal therapeutic targets

Fig. 5

A Flowchart for selecting HI genes using mRNA-sequencing data of 49 -7/del7q and 120 normal karyotype (NK) cases B ZNF277 was shown as an example of selected HI genes. ZNF277 expression levels of NK cases, -7/del7q before adjustment, and -7/del7q after adjustment were shown (left). Each expression level of -7/del7q cases was adjusted to 100% clonality using the slopes from estimated linear model (right). C Six common HI genes fitted our HI definition. D Correlation between copy number variation (CNV) and gene expression in 6 well-known HI genes.

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