Fig. 2: DELE1 is the most consistently downregulated gene in −5/del(5q) AML. | Leukemia

Fig. 2: DELE1 is the most consistently downregulated gene in −5/del(5q) AML.

From: DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

Fig. 2

A Volcano plot representation of the differential expression analysis conducted on RNAseq data comparing −5/del(5q) AML samples (n = 48) versus (left panel) other AML (n = 367) or (right panel) complex karyotype (CK) AML without −5/del(5q) (n = 27) as control. The horizontal dashed line indicates an adjusted p-value of 0.01 and vertical dashed lines indicate log fold change (logFC) of 1 and -1. Red and blue dots correspond to genes significantly over- and under-expressed (logFC > |1|, FDR < 0.01), respectively. Diamonds depict genes significantly downregulated and located on the chromosome 5q. B Dotplot representation (left panel) and density curves (right panel) of DELE1 expression in the −5/del(5q) cohort (n = 48, in blue), CK specimens without −5/del(5q) (n = 27, in gray) and other AML (n = 340, in black). Median values are indicated by red lines on each dotplot. Adjusted p-values resulting from the differential expression analysis are directly indicated on the figure. The color code for the −5/del(5q) group is representative of the median log-2 copy number ratio (log-2 ratio) calculated for the genomic region of DELE1 (window centered on the gene and extended for 25 kb on each side).

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