Table 1 Clinical characteristics of −5/del(5q) AML.

From: DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

 

−5/del(5q) (n = 48)

other (n = 367)

P-value

Age

65 (37–87)

57 (17–87)

<1e–3a

WBC (x109/L)

11.5 (0.8–321)

35.8 (0.8–447)

<1e–4a

Gender

  Female

21 (43.7%)

159 (43.3%)

—

  Male

27 (56.2%)

208 (56.7%)

—

Cytogenetic risk

  Adverse

48 (100%)

74 (20.1%)

<1e–4b

  Intermediate

0 (0%)

230 (62.7%)

—

  Favorable

0 (0%)

63 (17.2%)

—

Cytogenetic group

  CK

41 (85.4%)

27 (7.4%)

<1e–4b

FAB

  M0

8 (16.7%)

19 (5.2%)

<0.01b

  M1

7 (14.6%)

109 (29.7%)

<0.05b

  M2

7 (14.6%)

45 (12.3%)

—

  M3

0 (0%)

15 (4.1%)

—

  M4

2 (4.2%)

54 (14.7%)

—

  M5

1 (2.1%)

65 (17.7%)

—

  M6

5 (10.4%)

5 (1.4%)

—

  M7

1 (2.1%)

2 (0.5%)

—

  NC

17 (35.4%)

53 (14.4%)

—

  1. The “other” cohort is constituted of AML cases from diverse cytogenetic subgroups composing the Leucegene cohort.
  2. WBC white blood cell count, CK complex karyotype, FAB French-American-British.
  3. aMann–Whitney test.
  4. bFisher’s exact test.
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