Correction to: Leukemia https://doi.org/10.1038/s41375-023-02096-4, published online 25 November 2023

Publisher Correction

In this article, the wrong figure and legend appeared as Fig. 1E:

Fig. 1 NOTCH1 and USP11 expression levels are positively correlated in T-ALL. A Volcano plot showing Pearson correlation between 52 USPs and NOTCH1 mRNA levels in T-ALL patient samples analyzed from the Pediatric Cancer Genome Project data portal (PeCan, St. Jude, Memphis). B Pearson correlation between NOTCH1 and USP11 mRNA levels in T-ALL patient samples (source: PeCan). C RPKM values for NOTCH1 and USP11 in 176 blood cancer cell lines were obtained from https://software.broadinstitute.org/morpheus/, using the CCLE RNA sequencing data. These include 17 T-ALL cell lines, and all other cell lines were analyzed against these T-ALL cell lines. A two-tailed unpaired t-test was conducted using the RPKM values (****P < 0.0001). D Pearson correlation between NOTCH1 and USP11 mRNA levels in 17 T-ALL cell lines analyzed from CCLE RNA sequencing data. E Reverse-phase protein array (RPPA) for USP11 and intracellular NOTCH1 (N1IC) protein levels (n = 64). F Tracks showing NOTCH1, BRD4, and the activating histone marks H3K27Ac ChIP-Seq signal enrichment in T-ALL cells (CUTLL1) at the USP11 locus. G Heatmap representation of significant gene expression changes upon treatment of CUTLL1 cells with gamma-secretase inhibitor (γSI) followed by drug wash-off for 320’ (wash-off) [7]. Classical NOTCH1 targets (e.g., HES1, MYC, NRAPR) and the deubiquitinases USP7 and USP11 follow the intracellular NOTCH1 levels. H JURKAT T-ALL cells were treated with γSI (1 μM) for 24 h. RT-qPCR analysis of USP11 and other NOTCH1 targets was shown (*P < 0.05). I RT-qPCR analysis of Usp11 and Notch1 in normal mouse thymocytes and spleen cells isolated from N1ΔE induced mouse T-ALL model (*P < 0.05, ****P < 0.00001).

The figure and legend should have appeared as shown below:

Fig. 1 NOTCH1 and USP11 expression levels are positively correlated in T-ALL. A Volcano plot showing Pearson correlation between 52 USPs and NOTCH1 mRNA levels in T-ALL patient samples analyzed from the Pediatric Cancer Genome Project data portal (PeCan, St. Jude, Memphis). B Pearson correlation between NOTCH1 and USP11 mRNA levels in T-ALL patient samples (source: PeCan). C RPKM values for NOTCH1 and USP11 in 176 blood cancer cell lines were obtained from https://software.broadinstitute.org/morpheus/, using the CCLE RNA sequencing data. These include 17 T-ALL cell lines, and all other cell lines were analyzed against these T-ALL cell lines. A two-tailed unpaired t-test was conducted using the RPKM values (****P < 0.0001). D Pearson correlation between NOTCH1 and USP11 mRNA levels in 17 T-ALL cell lines analyzed from CCLE RNA sequencing data. E Reverse-phase protein array (RPPA) for USP11 and intracellular NOTCH1 (N1IC) protein levels (n = 61). F Tracks showing NOTCH1, BRD4, and the activating histone marks H3K27Ac ChIP-Seq signal enrichment in T-ALL cells (CUTLL1) at the USP11 locus. G Heatmap representation of significant gene expression changes upon treatment of CUTLL1 cells with gamma-secretase inhibitor (γSI) followed by drug wash-off for 320’ (wash-off) [7]. Classical NOTCH1 targets (e.g., HES1, MYC, NRAPR) and the deubiquitinases USP7 and USP11 follow the intracellular NOTCH1 levels. H JURKAT T-ALL cells were treated with γSI (1 µM) for 24 h. RT-qPCR analysis of USP11 and other NOTCH1 targets was shown (*P < 0.05). I RT-qPCR analysis of Usp11 and Notch1 in normal mouse thymocytes and spleen cells isolated from N1ΔE induced mouse T-ALL model (*P < 0.05, ****P < 0.00001).

The original article has been corrected.