Fig. 3: Aneuploidy is an early event in Eμ-Ret B-ALL progression.
From: The Eμ-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia
Representative G-banded karyotypes within the splenic preleukemic cell population of healthy Eμ-Ret mice, R222-6 (A) and R264-3 (B) showing chromosomal heterogeneity within the preleukemic cell population. Full reported karyotype is shown for each sample. C An M-FISH karyotype (from 5) for preleukemic sample (R224-2) revealing the presence of trisomy 14 and lack of large SVs. Full karyotype is provided below the image. D Range of chromosome numbers in normal splenocytes (10 cells, 2 mice), purified preleukemic cells (98 cells, 7 mice), and leukemic cells (17 cells, 2 mice) detected by G-banded karyotype analysis. Numbers detected in leukemia samples by CMA (18 mice) is shown in blue for comparison. E Heterogeneity of chromosomal involvement in preleukemic (n = 7), leukemic (n = 23, including both G-banded and CMA samples), and leukemia arising in NSG recipients (n = 3).
